005 STEROID FREE MAINTENANCE IMMUNOSUPPRESSION IN RENAL TRANSPLANTATION – A FOLLOW-UP OF 33 PATIENTS
نویسندگان
چکیده
منابع مشابه
Tacrolimus-based, steroid-free regimens in renal transplantation: 3-year follow-up of the ATLAS trial.
BACKGROUND Long-term use of corticosteroids is associated with considerable morbidity, including cardiovascular and metabolic adverse effects. METHODS This study evaluated the long-term efficacy and safety of two steroid-free regimens compared with a triple immunosuppressive therapy in renal transplant recipients. This was a 3-year follow-up to a 6-month, open-label, randomized, multicenter s...
متن کاملTowards Steroid-Free Immunosuppression after Liver Transplantation
The deleterious long-term side effects and metabolic complications of corticosteroids have inspired initial clinical investigation of corticosteroid withdrawal and avoidance protocols in liver transplantation. The original studies in the 1990s focused on the safety of steroid withdrawal in patients without hepato-cellular carcinoma (HCC). 1,2 Subsequent clinical trials suggested noninferiority ...
متن کاملHLA-mismatched renal transplantation without maintenance immunosuppression.
Five patients with end-stage renal disease received combined bone marrow and kidney transplants from HLA single-haplotype mismatched living related donors, with the use of a nonmyeloablative preparative regimen. Transient chimerism and reversible capillary leak syndrome developed in all recipients. Irreversible humoral rejection occurred in one patient. In the other four recipients, it was poss...
متن کاملRole of Immunosuppression Minimization Protocols in Renal Transplantation
The subject of transplant immunosuppression has generated significant interest in recent years. Excellent immunosuppression, advances in surgical technique, post-transplantation care, and infection control have resulted in excellent outcomes. There is widespread support for the notion that the fundamental objective in transplant immunology should be the achievement of specific graft toleran...
متن کاملCompletely steroid-free immunosuppression in liver transplantation: a randomized study.
INTRODUCTION Corticosteroids (CS) have been standard immunosuppression to prevent and treat rejection. However, CS are associated with increased risk of infection, obesity, hypertension, hyperlipidemia, diabetes, and accelerated hepatitis C virus (HCV) recurrence post-orthotopic liver transplantation (OLT). This study assesses the safety and efficacy of CS-free immunosuppressive regimen in adul...
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ژورنال
عنوان ژورنال: Indian Journal of Transplantation
سال: 2011
ISSN: 2212-0017
DOI: 10.1016/s2212-0017(11)60125-1